Mouse Cleaning Tips
On a mechanical mouse, the little wheels get
gunk in them, so clean them. Just remove the mouse ball and examine the wheels.
I've used rubbing alcohol and a Q-tip to get the gunk off the wheels. Clean the
mouse about twice a year, unless your desk is covered with dirt and dust, as
dirt and dust are just gunk in it's fetal stages.

If you have an optical mouse, just clean the sensors: you can often just polish
them with a soft cloth. Remember to keep the mouse pad clean as well so that the
grid lines are visible to the sensors.
Mouse Troubleshooting Tips:
1. Check is your mouse plugged in? On the back of your computer there is a PS/2
port, check to see if your mouse cable is fully plugged in.
2. Check the mouse software driver, You can try reinstalling the mouse drives.
Check the mouse driver set-up is it set-up correctly?